NOS3 and sarcopenia: Khanal et al. (2020) reported that using the %SMM definition of sarcopenia, the NOS3 rs1799983 variant was identified as another influential factor, as individuals with the GG genotype faced a 2.26 times greater likelihood of developing sarcopenia compared to that for T-allele carriers, pointing to a possible link between nitric oxide signaling and muscle preservation [22].