Occasionally, these two B-cell lymphomas present with similar morphological features and overlapping characteristics, with many being classified as either high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBCL-DH or HGBL-TH) or as high-grade B-cell lymphomas, not otherwise specified (HGBCL, NOS). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.