The effects of pre-meal water intake on copeptin, glucose metabolism, lipid regulation and anthropometric indices were also examined in a randomized study of 40 patients with T2D by Sedaghat et al. Increasing pre-meal water intake over eight weeks reduced copeptin, fasting glucose, triglycerides, LDL levels, waist circumference and BMI [80]. This evidence concerns the gene AVP and type 2 diabetes mellitus.