Among diabetes patients with osteoporosis (OP) at the femoral neck (FN), there was a significant increase in menopause duration (16.33 ± 20.65 years), age (67.67 ± 8.14 years), ALP (115.67 ± 20.26 U/L), PTH (103.1 ± 79.1 pg/mL), and total calcium (2.27 ± 0.32 mmol/L), along with a significant reduction in estrogen (8.53 ± 6.11 pg/mL), albumin (35.87 ± 1.86 g/L), BMI (30.28 ± 4.97 kg/m2), and LS T-score (−3.57 ± 0.49). This evidence concerns the gene PTH and diabetes mellitus.