TNF and obesity due to melanocortin 4 receptor deficiency: It also increases the content of serum cytokine IL-4, reduces the content of IL-1β, increases the expression level of PPAR-γ, AMPK, and P-AMPK protein, inhibits lipogenesis, improves lipid metabolism disorder, reduces the expression of IL-1β, TNF-α, and other proteins in epididymal adipose tissue, and improves tissue inflammation caused by obesity through regulating the PPAR/AMPK signaling pathway.