PSMB6 and neurodevelopmental disorder: Furthermore, the remaining five candidate genes demonstrate multidimensional associations with neurodevelopmental disorders through distinct mechanisms as follows: epigenetic regulation (Dnmt3a [86]), cytoskeletal dynamics (Ccdc88a [87]), autophagy (Becn1 [88]), proteostasis (Psmb6 [89]), and transcriptional control (Gng2 [90]).