Kidney biopsies from patients with progressive CKD revealed the upregulation of inflammatory pathways involving genes such as CCL19, CXCL1, IFNAR2, NCK2, PTK2B, PTPRC, RASGRP1, and TNFRSF25, as well as an increased expression of transcripts involved in apoptosis, including MAP3K14, TNFRSF10B/TRAIL-R2, TRADD, and TRAF2 [8]. This evidence concerns the gene TNFRSF10B and chronic kidney disease.