In yeast overexpression systems, SLC25A46 interacts with mitofusin 2 (MFN2) and optic atrophy 1 (Opa1) genes which are associated with CMT2A (MFN2) and optic atrophy (Opa1) [22,23,25]. The gene discussed is OPA1; the disease is Leber hereditary optic neuropathy.