RET and melanoma: In neural crest, melanocyte, and melanoma cells, PAX3 was found to regulate MITF, NGN2, RET, SOSTDC1, MSX2, DCT, and TYRP1 genes [5,6,26,27,28,29,30,31,32], as well as genes expressed ubiquitously or widely (and including melanocytes), such as BCL-XL, CXCR4, FGFR4, HES1, MET, NF1, TGFb2, and WNT1 [11,30,33,34,35,36,37,38,39,40,41,42].