By bringing together a comprehensive analytic pipeline that included lead SNP-to-nearest gene mapping to link the SNPs to their most probable effector genes, immune-related gene annotation for the nearest genes, correlation of immune-annotated nearest genes with anti-tumor immune response signatures in tumor bulk and single-cell RNA-Seq data, we prioritized five genes: IRF1, IKZF1, SPI1, SH2B3 and LAT. The gene discussed is SPI1; the disease is neoplasm.