There are three notable features of this finding: the gene nearest to rs231779 is CTLA4, the allele of rs231779 that increases autoimmune disease risk is protective for melanoma and keratinocyte cancers and rs231779, while being associated with melanoma risk (p = 3.6 × 10−4), did not reach the conventional genome-wide significance threshold (p < 5 × 10−8). Here, CTLA4 is linked to melanoma.