Using PDX models that retained the antigenic profiles of the primary tumors, it was shown that PSCA-targeted CAR-T cells could effectively inhibit NSCLC tumor growth in PDX mice and synergistically eradicate PSCA + MUC1 + tumors in combination with MUC1-targeted CAR-T cells [65]. This evidence concerns the gene MUC1 and non-small cell lung carcinoma.