Q. Wang et al. conducted genome-wide CRISPR/Cas9 screening in two NSCLC cell lines (NCI-H460 and A549) containing p53 wild-type and receptor tyrosine kinase (wt p53-RTK) genes using the GeCKO v2.0 lentiviral library (comprising 123,411 small guide RNAs [sgRNAs] targeting 19,050 human genes) [52]. This evidence concerns the gene TP53 and non-small cell lung carcinoma.