In acute myocardial infarction mouse models, five genes (Ptpn6, Csf1r, Col6a1, Cyba, and Map3k14) have been implicated in the acute myocardial infarction pathway by regulating DNA methylation, suggesting their potential as early methylated biomarkers for clinical diagnosis [44]. This evidence concerns the gene COL6A1 and acute myocardial infarction.