In acute myocardial infarction mouse models, five genes (Ptpn6, Csf1r, Col6a1, Cyba, and Map3k14) have been implicated in the acute myocardial infarction pathway by regulating DNA methylation, suggesting their potential as early methylated biomarkers for clinical diagnosis [44]. The gene discussed is PTPN6; the disease is acute myocardial infarction.