Malignancies like MPNST often develop through a multistep genetic process involving the somatic loss of genes like NF1, CDKN2A/B, SUZ12, or EED, combined with epigenetic deregulation, including the loss of H3K27me3 and hypermethylation of key genes like SOX10 and CDKN2A [48]. Here, SUZ12 is linked to malignant peripheral nerve sheath tumor.