For example, in a study published in the Journal of Dental Research in 2024 [9], “Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis”, we describe the use of the Xenium In Situ platform—using a custom-designed panel of 350 palate-specific gene markers—to identify and spatially resolve the transcription of Dkk1 and Dkk2 to the osteogenic zones and mesial border within the midline of palatine bones in the murine Pax9−/− cleft palate, respectively. Here, DKK2 is linked to cleft palate.