Very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is one of the conditions included in the newborn Italian screening, and it is caused by biallelic pathogenic variants in ACADVL (acyl-CoA dehydrogenase very-long-chain), resulting in the impairment of fatty acid oxidation with the accumulation of long-chain acylcarnitines [3]. This evidence concerns the gene ACADVL and long chain acyl-CoA dehydrogenase deficiency.