We identified 12 cancer genes associated with recurrently up-regulated REs (CDK1, ESCO2, GAS5, GTSE1, H2BC12, KIFC1, MMS22L, NF1, NIT2, PVT1, STAT1, UBE2C) and 19 cancer genes associated with recurrently down-regulated REs (ADAMTS9-AS2, ATF3, CASP8, DCN, DUSP1, ECT2L, EMP1, FANCC, JDP2, KLF6, NDRG2, NR4A1, RHOBTB2, SOCS2, SPARCL1, STARD13, SYNPO2, TAGLN, TIMP3). The gene discussed is RHOBTB2; the disease is cancer.