The study also identified six individuals with disorders comprising genes that encode components or regulators of the Ras/mitogen-activated protein kinase (MAPK) pathway (RASopathies), including two with Noonan syndrome, two with Noonan syndrome with multiple lentigines, one with Noonan syndrome-like, and another with neurofibromatosis-Noonan phenotype. The gene discussed is WNK2; the disease is RASopathy.