AGTR2 and hypertrophic cardiomyopathy: In addition, in a family cohort of patients with hypertrophic cardiomyopathy (HCM), Carstens et al. found a decrease in average wall thickness of ~0.5 mm with each AGTR2:1675A allele independent of the effects of the primary HCM causal mutation, blood pressure and other hypertrophy covariates [24].