However, in patients with hypertrophic cardiomyopathy, Carstens et al. reported an allele-dependent modulating effect of the AGTR2:rs1403543 polymorphism on LVH (with a decrease in wall thickness by ~0.5 mm with each 1675A allele) which was independent of such covariates as causal mutation of hypertrophic cardiomyopathy or blood pressure [25]. This evidence concerns the gene AGTR2 and hypertrophic cardiomyopathy.