Insulin-like growth factor 1 (IGF-1) levels were persistently increased (645.48 ± 1.17 ng/mL versus 635.40 ± 1.28 ng/mL; p = 0.011), a result frequently seen in people with significant obesity and preserved GH responsiveness. The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.