SARS1 and microcephaly: With reference to aminoacyl-tRNA synthetase, a study [38] on ARS deficiencies showed that serine supplementation ranging from 85.7 to 97.5 mg/kg/day in fibroblasts of patients with Seryl-tRNA synthetase 1 (SARS) enabled improvements in height and development, as well as resolution of microcephaly.