A recently published study described an infant with LARS1 deficiency and hypoalbuminemia who underwent a one month of Leu supplementation (300 mg/day) combined with a high-protein diet, with no observed effect on albumin levels and no reported side effects, and a report on a patient with IARS1 deficiency who received Ile supplementation (200 mg/kg/day), which led to improvements in feeding, development, and susceptibility to infections [39]. Here, ALB is linked to hyperinsulinemic hypoglycemia, familial, 4.