ALKBH5 and obesity due to melanocortin 4 receptor deficiency: Furthermore, in human cohorts, the study found that the writers WTAP and VIRMA, the eraser ALKBH5, and reader proteins such as YTHDF1, YTHDF2, and YTHDC1 are associated with obesity by comparing gene expression of m6A regulators in adipose tissue between individuals with obesity and lean controls.