ALKBH5 and obesity due to melanocortin 4 receptor deficiency: Hepatocyte-specific deletion of Alkbh5 improves glucose tolerance and mitigates metabolic dysfunction-associated fatty liver disease (MAFLD) in obesity by inhibiting GCGR–cyclic adenosine monophosphate (cAMP) and EGFR–PI3K–AKT–mTORC1 signaling.