In patients with colorectal cancer (CRC), METTL3 enhances the stability of hexokinase 2 (HK2) and glucose transporter GLUT1 mRNAs by interacting with their 3′UTR regions, with the stability of HK2 and GLUT1 being mediated by IGF2BP2 and IGF2BP3, respectively. This evidence concerns the gene HK2 and colorectal cancer.