Pathogenic variants in the FGFR1 (fibroblast growth factor receptor 1) gene can cause broad phenotypic spectrum, including Hartsfield syndrome, Jackson–Weiss syndrome, Kallmann syndrome (KS) type 2, hypogonadotropic hypogonadism without hyposmia (HH), osteoglophonic dysplasia, Pfeiffer syndrome, and Trigonocephaly 1 via autosomal-dominant inheritance [9,10,11,12,13,14]. The gene discussed is FGFR1; the disease is isolated trigonocephaly.