Pathogenic variants in the FGFR1 (fibroblast growth factor receptor 1) gene can cause broad phenotypic spectrum, including Hartsfield syndrome, Jackson–Weiss syndrome, Kallmann syndrome (KS) type 2, hypogonadotropic hypogonadism without hyposmia (HH), osteoglophonic dysplasia, Pfeiffer syndrome, and Trigonocephaly 1 via autosomal-dominant inheritance [9,10,11,12,13,14]. This evidence concerns the gene FGFR1 and trigonocephaly 1.