Several SNPs of the NRF2 gene have repercussions on certain antioxidant enzymes, for example, rs2234694 is related to SOD1, rs2536512 to SOD3, rs1056806 to GSTM1, rs4880 to SOD2 and rs1800668 to GPx1; all were found in obese patients and were associated with increased risk of obesity [52]. The gene discussed is GPX1; the disease is obesity due to melanocortin 4 receptor deficiency.