Previous research has shown that male Leu allele (T) carriers have higher prevalence of metabolic syndrome, increased waist-to-hip ratio, triglycerides, HOMA-β (Homeostasis Assessment Model for pancreas functioning) and blood pressure as well, while women carriers had higher BMI, insulin and HOMA-IR (Homeostasis Assessment Model for insulin resistance) index (Table 1) [8]. Here, INS is linked to Insulin resistance.