PKD1 and autosomal dominant polycystic kidney disease: ADPKD is a genetically heterogeneous condition, with monoallelic pathogenic variants in PKD1 (encoding polycystin-1, PC1 (MIM: 601313)) and PKD2 (encoding polycystin-2, PC2 (MIM: 173910)) accounting for approximately 78% and 15% of cases, respectively [3].