For the monocyte immune cells, all traits were linked with increased osteoporosis risk: HLA DR on CD14+ CD16− monocyte (IVW: odds ratio [OR] 1.1029, 95% confidence interval [CI] 1.0651–1.1420; p = 0.000), HLA DR on CD14+ monocyte (IVW: odds ratio [OR] 1.1014, 95% confidence interval [CI] 1.0625–1.1418; p = 0.000), and HLA DR on monocyte (IVW: odds ratio [OR] 1.0562, 95% confidence interval [CI] 1.0181–1.0958; p = 0.004). This evidence concerns the gene CD14 and osteoporosis.