Two cDC immune cells were linked with increased osteoporosis risk: HLA DR on plasmacytoid DC (IVW: odds ratio [OR] 1.0497, 95% confidence interval [CI] 1.0167–1.0837; p = 0.003), and HLA DR on DC (IVW: odds ratio [OR] 1.0718, 95% confidence interval [CI] 1.0253–1.1205; p = 0.002); the other cDC cell was linked with decreased osteoporosis risk: CD11c+ CD62L− monocyte %monocyte (IVW: odds ratio [OR] 0.9102, 95% confidence interval [CI] 0.8624–0.9735; p = 0.005). This evidence concerns the gene ITGAX and osteoporosis.