A small Colombian study reviewed the sputum biomarkers of women with COPD secondary to tobacco or wood burning smoke and demonstrated that the women with COPD demonstrate higher sputum levels of IL-8, metalloproteinase 9 (MMP-9), and chemokine ligand 5 (CCL5) than the control groups [65]. Here, CXCL8 is linked to chronic obstructive pulmonary disease.