The observation that T1DM autoantibodies precede anti-tTG autoantibodies more often (67%) than vice versa (27%), as evidenced by the TEDDY (The Environmental Determinants of Diabetes in the Young) prospective birth cohort study (which included children at high HLA genetic risk of both T1DM and CD), could be consistent with the aforementioned hypothesis and, accordingly, a preexisting T1DM autoimmune background may further promote the development of CD autoimmunity [92]. Here, TGM2 is linked to type 1 diabetes mellitus.