IL1R1 and rheumatoid arthritis: Another study conducted by Meusch and colleagues showed that following the activation of RS of tmTNF of monocytes, increased secretion of soluble forms of TNF and IL-1 receptors (sTNFR1 and sIL-1R1) and IL-10 was correlated with a good therapeutic response to ETA in patients with rheumatoid arthritis according to EULAR criteria [21].