Mutations in IDH1 and IDH2 are reported in 5 to 15% of AML cases, respectively, being p.Arg132X (NM_005896.4:IDH1) and p.Arg140X, p.Arg172X (NM_002168.4:IDH2 the most frequent alterations) [6,7]. The gene discussed is IDH1; the disease is acute myeloid leukemia.