BCR and Familial prostate cancer: By contrast, the MRMR-CNNFormer in our current study uniquely integrates multi-region (intratumoral, peritumoral, and periprostatic) and multi-sequence (T2WI-FS and DWI) MRI images with clinical parameters, capturing critical microenvironmental interactions that significantly enhance prostate cancer BCR prediction after radical prostatectomy (with an AUC of 0.835 and an accuracy of 0.819 on the independent external testing cohort (n = 50)).