One-way ANOVA showed that the TWIK complex signature exhibited significant correlations with the clinicopathological indices, including the pathological tumour stage, pathological node stage, overall TNM stage, Gleason score, ISUP grade group score, response to androgen deprivation therapy, prostate-specific antigen levels, and fraction genome altered (FGA) (Table S1). The gene discussed is KLK3; the disease is neoplasm.