LPL and cancer: Additionally, the tumor mutational burden (TMB) analysis results for LPL indicated a significant positive correlation with TMB in five types of cancer, namely GBM, LAML, THYM, OV, and ACC (p < 0.05), but a negative correlation with TMB in thirteen types of cancer including GBMLGG, LGG, LUAD, COAD, and COADREAD (Figure 6f).