Supplementation of 4-month-old AD-mice (APPsw/Tg2576) for 15 months with 4% pomegranate attenuated lipid peroxidation and protein carbonylation, and restored the activities of crucial antioxidant effectors SOD, catalase (CAT), glutathione peroxidase (GPx), Glutathione reductase (GSH) and Glutathione S transferase (GST) in hippocampus and the cerebral cortex [83]. This evidence concerns the gene SOD1 and Alzheimer disease.