The combination of berberine with multiple ferroptosis inducers, including sulfasalazine (SAS), RSL3, FIN56, and dihydroartemisinin (DHA), synergistically suppressed NSCLC by depleting GSH via the p53-dependent SLC7A11-GPX4 pathway. The gene discussed is SLC7A11; the disease is non-small cell lung carcinoma.