PAK4 and posterior cortical atrophy: Indeed, some therapeutic systems, including a prostate-specific four-antigen cassette expressing PSA, IRE, PAK4 inhibitors, and zoledronic acid-peptide vaccines, show a synergistic antitumor effect in PCa when combined with ICB due to the augmented CD8+ T-cell infiltration or reactivation of CD8+ T cells in tumors [119,122].