PIK3CA and breast cancer: The upregulated PIK3CA and PIK3R1 across all BC subtypes, as key regulators of the PI3K/AKT/mTOR pathway, could potentially be modulated by these polyphenols, inhibiting this pathway through disruption of phosphorylation and conformational changes in the catalytic and regulatory subunits [157], alongside the regulation of the downstream effectors, such as STAT3 and STAT1.