The same compound enhanced the 5-fluorouracil-induced cytotoxicity in colorectal cell lines, promoted apoptosis and cell cycle arrest to inhibit the drug-resistant cell lines, and suppressed self-renewal proteins Notch1, Bmi1, Suz12, and Ezh2 expressions, stimulating the tumor suppressive micro RNAs [130]. This evidence concerns the gene BMI1 and neoplasm.