So far, members of this family and, in particular, UBQL4 have been associated with the most common cancers [78], while another member, namely, UBQLN1, has been shown to be critical in combating neurological disorders caused by protein aggregation, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and Huntington’s disease, while its loss has so far been found in lung cancer patients and human cancer cell lines [79]. This evidence concerns the gene UBQLN1 and amyotrophic lateral sclerosis.