Commonly used models of RA include collagen-induced arthritis (CIA), collagen antibody-induced arthritis (CAIA), adjuvant-induced arthritis (AIA), K/BxN serum-transfer, TNF transgenic (hTNFtg) and pristine-induced arthritis (PIA) which are used to predict drug efficacy and study disease mechanisms [11]. Here, TNF is linked to rheumatoid arthritis.