SIRT1 and fatty liver disease: In animal models of fatty liver, 60 mg/kg curcumin decreased malondialdehyde levels and increase glutathione peroxidase activity [50], whilst 50 mg/kg decreased ROS and increased superoxide dismutase and sirtuin-1 [51], suggesting curcumin can reduce oxidative stress and lipid peroxidation, via its antioxidant properties and protective effects against cellular damage.