Glutamate clearance and production, processes controlled by Glu transporters and Glutamine Synthetase, are abnormal in Mecp2-deficient astrocytes in vitro, probably contributing to the pathological process of RTT [56], and mRNA expression of Glast and Glt-1 glutamate transporters is decreased in Mecp2-null astrocytes [56]. This evidence concerns the gene SLC1A3 and Rett syndrome.