IL1B and psoriasis: For example, keratinocytes activate DC to produce IL-1β and IL-6 through IL-36, produce overexpressed LL37 to activate macrophages [20], regulate their own self-expression of IL-1 family cytokines, induce immune cells to produce chemokines, participate in the recruitment of neutrophils in the early stage of psoriasis [21], and further promote inflammation.