AKT1 and ovarian carcinoma: In addition, Xing et al., reported that wogonin enhanced the sensitivity of ovarian cancer cells to gemcitabine by inhibiting the PI3K/Akt signaling pathway [133], while bioinformatics results predicted that wogonin promoted PDA cell apoptosis by inhibiting protein kinase B (Akt) signaling, thereby enhancing the sensitivity of gemcitabine to PDA [134].