Agarwal et al. [116] analyzed the changes in bone marrow mesenchymal cell populations induced by leukemia using mouse CML models, revealing that tumor necrosis factor α (TNF-α) enhances LSC maintenance and growth by mediating the CXCL1-CXCR2 signaling axis in the CML bone marrow microenvironment. The gene discussed is CXCR2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.