CXCR acts as a specific receptor for CXCLs with high affinity, forming a “receptor–ligand” biological axis; for instance, the CXCL12/CXCR4-7 regulatory axis serves as a pivotal molecular network in the initiation and progression of hematological malignancies, and the CXCL12/CXCR4 axis regulates the homing of leukemic cells to the bone marrow and their mobilization into the bloodstream through intricate interactions. This evidence concerns the gene CXCL12 and hematologic disorder.