In addition, Lewis et al. [129], by preparing and using an acquired CXCR4 mutant mouse model with the overactivation of CXCR4 signal transduction, confirmed that CXCR4 overactivation would lead to disease progression and a more aggressive phenotype in the mouse Eμ-TCL1 CLL model. Here, CXCR4 is linked to B-cell chronic lymphocytic leukemia.