A prime example is CD30, a 120 kDa type I membrane protein, which has been extensively studied and has become integral to the nomenclature of primary cutaneous CD30-positive lymphoproliferative disorders, such as lymphomatoid papulosis (LyP), anaplastic large cell lymphoma (ALCL), and transformed MF [45]. The gene discussed is TNFRSF8; the disease is lymphoproliferative syndrome.