A recent study demonstrated that simvastatin, an anti-cholesterol drug, prevented cognitive defects in adult and aged wild-type mice that did not undergo a high-cholesterol diet and adult TGF-beta mice that underwent a high-cholesterol diet by targeting white matter inflammation and Galectin-3 (Gal-3) microglial cells, implicated in Alzheimer’s and upregulated in brain injuries [110,111]. This evidence concerns the gene LGALS3 and Cognitive impairment.