In vitro TNF stimulates the proliferation of fibroblasts [49], astrocytes [50], macrophages [51], T-lymphocytes, and B-lymphocytes [52,53,54,55], but has a cytotoxic effect on various tumor cell lines [56] and normal cells, such as endothelial [57,58], oligodendrocytes [59], thyrocytes [60], and fibroblasts [61]. Here, TNF is linked to neoplasm.