Multiple immune cell types contribute to TNF production in TB, including monocytes, macrophages, dendritic cells, neutrophils, and various T cell subsets—such as CD4+, CD8+, γδ T cells, NKT cells, and CD1-/MR1-restricted T cells [38,137,138,139,140,141,142,143,144,145]. Here, CD4 is linked to tuberculosis.