Studies demonstrate that STs enhance the binding capacity of MM cells to adhesion molecules (e.g., VCAM1, MADCAM1, and E-selectin) on bone marrow endothelial cells by catalyzing sialylation modifications of integrins α4β1/α4β7 and selectin ligands (e.g., SLea/x), thereby driving tumor cell homing to the bone marrow microenvironment (BMM) [92,93,94]. This evidence concerns the gene SELE and neoplasm.