HMOX1 and idiopathic membranous glomerulonephritis: Melatonin upregulated heme oxygenase 1 (HO1) expression, diminished the production of ROS, reduced the expression of pro-inflammatory cytokines and increased the expression of anti-inflammatory cytokines, thereby ameliorating idiopathic membranous nephropathy, an autoimmune-mediated glomerulonephritis, in a murine model [221].