LYZ and infection: Paneth cells, on the other hand, located in Lieberkühn’s crypts, that are small invaginations lining the surface of the mucosa, secrete AMP-rich granules such as lysozyme and various antibacterial proteins such as α-defensins, lysozymes, secretory phospholipase A2, angiogenin-4, RegIIIγ, RegIIIβ and α1-antitrypsin that help defend the host against infection and maintain a balanced microbiota [53].