TNF and rheumatoid arthritis: In conclusion, TAAs, primarily CA15-3 and HE4 but also others, might show two-way associations with other parameters of RA including DAS28, markers of inflammation (CRP, ESR), cytokines (TNF-α, IL-6, IL-8, VEGF), PECAM-1, as well as the ccIMT and cfPWV vascular pathophysiology markers.